Analysis of histological therapeutic effect, apoptosis rate and p53 status after combined treatment with radiation, hyperthermia and 5-fluorouracil suppositories for advanced rectal cancers.

The tumour-suppressor gene p53 encodes a transcription factor that plays a critical role in the induction of G1 cell cycle arrest and apoptosis after DNA damage. To clarify the role of the p53 gene and apoptosis in combined hyperthermia, chemotherapy and radiation (hyperthermochemoradiotherapy, HCR...

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Main Authors: Sakakura, C., Koide, K., Ichikawa, D., Wakasa, T., Shirasu, M., Kimura, A., Taniguchi, H., Hagiwara, A., Yamaguchi, T., Inazawa, J., Abe, T., Takahashi, T., Otsuji, E.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1998
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151276/
https://ncbi.nlm.nih.gov/pubmed/9459162
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