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Degradation of histone mRNA requires oligouridylation followed by decapping and simultaneous degradation of the mRNA both 5′ to 3′ and 3′ to 5′

Histone mRNAs are rapidly degraded at the end of S phase or when DNA replication is inhibited. Histone mRNAs end in a conserved stem–loop rather than a poly(A) tail. Degradation of histone mRNAs requires the stem–loop sequence, which binds the stem–loop-binding protein (SLBP), active translation of...

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書目詳細資料
Main Authors: Mullen, Thomas E., Marzluff, William F.
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2151014/
https://ncbi.nlm.nih.gov/pubmed/18172165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1622708
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