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Dense core secretory vesicles revealed as a dynamic Ca(2+) store in neuroendocrine cells with a vesicle-associated membrane protein aequorin chimaera

The role of dense core secretory vesicles in the control of cytosolic-free Ca(2+) concentrations ([Ca(2+)](c)) in neuronal and neuroendocrine cells is enigmatic. By constructing a vesicle-associated membrane protein 2–synaptobrevin.aequorin chimera, we show that in clonal pancreatic islet β-cells: (...

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Detalhes bibliográficos
Main Authors: Mitchell, Kathryn J., Pinton, Paolo, Varadi, Aniko, Tacchetti, Carlo, Ainscow, Edward K., Pozzan, Tullio, Rizzuto, Rosario, Rutter, Guy A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2150797/
https://ncbi.nlm.nih.gov/pubmed/11571310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200103145
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