I-Band Titin in Cardiac Muscle Is a Three-Element Molecular Spring and Is Critical for Maintaining Thin Filament Structure

In cardiac muscle, the giant protein titin exists in different length isoforms expressed in the molecule's I-band region. Both isoforms, termed N2-A and N2-B, comprise stretches of Ig-like modules separated by the PEVK domain. Central I-band titin also contains isoform-specific Ig-motifs and no...

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Detalhes bibliográficos
Principais autores: Linke, Wolfgang A., Rudy, Diane E., Centner, Thomas, Gautel, Mathias, Witt, Christian, Labeit, Siegfried, Gregorio, Carol C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1999
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2150553/
https://ncbi.nlm.nih.gov/pubmed/10444071
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