Alterations of TP53 in microdissected transitional cell carcinoma of the human urinary bladder: high frequency of TP53 accumulation in the absence of detected mutations is associated with poor prognosis.

We have used microdissection of paraffin-embedded histological sections and polymerase chain reaction (PCR)-based direct DNA sequencing for 54 transitional cell carcinoma (TCC) of the bladder, to examine critically the association between TP53 nuclear accumulation determined by immunohistochemistry...

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Main Authors: Abdel-Fattah, R., Challen, C., Griffiths, T. R., Robinson, M. C., Neal, D. E., Lunec, J.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 1998
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2150401/
https://ncbi.nlm.nih.gov/pubmed/9649138
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