Mutations in residues of TP53 that directly contact DNA predict poor outcome in human primary breast cancer.

The tumour-suppressor gene TP53 is frequently mutated in breast tumours, and the majority of the mutations are clustered within the core domain, the region involved in DNA binding. We searched for alterations in this central domain of the TP53gene in 222 human breast cancer specimens using polymeras...

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Bibliographic Details
Main Authors:	Berns, E. M., van Staveren, I. L., Look, M. P., Smid, M., Klijn, J. G., Foekens, J. A.
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group 1998
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2150115/ https://ncbi.nlm.nih.gov/pubmed/9569050
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Mutations in residues of TP53 that directly contact DNA predict poor outcome in human primary breast cancer.

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