The demonstration of in vivo misonidazole tumour toxicity using post radiation hypoxia.

The cytotoxic effect of the radiosensitizer misonidazole on hypoxic tumour cells in vivo has been studied. Using standard procedures of large single doses of X-ray (30 Gy) followed by 1.0 mg/g misonidazole, no significant cytotoxicity (measured by tumour regrowth) could be observed. In contrast, whe...

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Main Authors: Gomer, C. J., Johnson, R. J., Hetzel, F. W., Lawrence, G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1978
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2149367/
https://ncbi.nlm.nih.gov/pubmed/277234
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