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Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia
Evolutionarily significant selective sweeps may result in long stretches of homozygous polymorphisms in individuals from outbred populations. We developed whole-genome homozygosity association (WGHA) methodology to characterize this phenomenon in healthy individuals and to use this genomic feature t...
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| 主要な著者: | , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2148402/ https://ncbi.nlm.nih.gov/pubmed/18077426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710021104 |
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