Consistent, persistent expression from modified retroviral vectors in murine hematopoietic stem cells

Retroviral vectors based on the Moloney murine leukemia virus (MoMuLV) have shown inconsistent levels and duration of expression as well as a propensity for the acquisition of de novo methylation in vivo. MoMuLV-based vectors are known to contain sequences that are capable of suppressing or preventi...

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Main Authors: Robbins, Paul B., Skelton, Dianne C., Yu, Xiao-Jin, Halene, Stephanie, Leonard, Earl H., Kohn, Donald B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The National Academy of Sciences 1998
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC21482/
https://ncbi.nlm.nih.gov/pubmed/9707621
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