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Sustained pharmacological inhibition of δPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats

Hypertensive encephalopathy is a potentially fatal condition associated with cerebral edema and the breakdown of the blood-brain barrier (BBB). The molecular pathways leading to this condition, however, are unknown. We determined the role of δPKC, which is thought to regulate microvascular permeabil...

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Detalhes bibliográficos
Main Authors: Qi, Xin, Inagaki, Koichi, Sobel, Raymond A., Mochly-Rosen, Daria
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2147668/
https://ncbi.nlm.nih.gov/pubmed/18097471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32636
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