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Conformational transitions and fibrillation mechanism of human calcitonin as studied by high-resolution solid-state 13C NMR.

Conformational transitions of human calcitonin (hCT) during fibril formation in the acidic and neutral conditions were investigated by high-resolution solid-state 13C NMR spectroscopy. In aqueous acetic acid solution (pH 3.3), a local alpha-helical form is present around Gly10 whereas a random coil...

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Autori principali: Kamihira, M., Naito, A., Tuzi, S., Nosaka, A. Y., Saitô, H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 2000
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2144639/
https://ncbi.nlm.nih.gov/pubmed/10850796
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