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Distinguishing between sequential and nonsequentially folded proteins: implications for folding and misfolding.

We describe here an algorithm for distinguishing sequential from nonsequentially folding proteins. Several experiments have recently suggested that most of the proteins that are synthesized in the eukaryotic cell may fold sequentially. This proposed folding mechanism in vivo is particularly advantag...

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Bibliographic Details
Main Authors: Tsai, C. J., Maizel, J. V., Nussinov, R.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 1999
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2144423/
https://ncbi.nlm.nih.gov/pubmed/10452603
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