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Functional analyses of AmpC beta-lactamase through differential stability.

Despite decades of intense study, the complementarity of beta-lactams for beta-lactamases and penicillin binding proteins is poorly understood. For most of these enzymes, beta-lactam binding involves rapid formation of a covalent intermediate. This makes measuring the equilibrium between bound and f...

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Main Authors: Beadle, B. M., McGovern, S. L., Patera, A., Shoichet, B. K.
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 1999
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2144403/
https://ncbi.nlm.nih.gov/pubmed/10493583
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