Production of soluble alphabeta T-cell receptor heterodimers suitable for biophysical analysis of ligand binding.

A method to produce alphabeta T-cell receptors (TCRs) in a soluble form suitable for biophysical analysis was devised involving in vitro refolding of a TCR fusion protein. Polypeptides corresponding to the variable and constant domains of each chain of a human and a murine receptor, fused to a coile...

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Detalhes bibliográficos
Main Authors: Willcox, B. E., Gao, G. F., Wyer, J. R., O'Callaghan, C. A., Boulter, J. M., Jones, E. Y., van der Merwe, P. A., Bell, J. I., Jakobsen, B. K.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 1999
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2144200/
https://ncbi.nlm.nih.gov/pubmed/10595544
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