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Overexpression of recombinant proteins with a C-terminal thiocarboxylate: implications for protein semisynthesis and thiamin biosynthesis.

A facile and rapid method for the production of protein C-terminal thiocarboxylates on DNA-encoded polypeptides is described. This method, which relies on the mechanism of the cleavage reaction of intein-containing fusion proteins, can produce multi-milligram quantities of protein C-terminal thiocar...

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Main Authors: Kinsland, C., Taylor, S. V., Kelleher, N. L., McLafferty, F. W., Begley, T. P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cold Spring Harbor Laboratory Press 1998
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2144084/
https://ncbi.nlm.nih.gov/pubmed/10082383
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