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Conformational change in the activation of lipase: an analysis in terms of low-frequency normal modes.

The interfacial activation of Rhizomucor miehei lipase (RmL) involves the motion of an alpha-helical region (residues 82-96) which acts as a "lid" over the active site of the enzyme, undergoing a displacement from a "closed" to an "open" conformation upon binding of sub...

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Autori principali: Jääskeläinen, S., Verma, C. S., Hubbard, R. E., Linko, P., Caves, L. S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory Press 1998
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2144042/
https://ncbi.nlm.nih.gov/pubmed/9655340
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