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Computation of electrostatic complements to proteins: a case of charge stabilized binding.

Recent evidence suggests that the net effect of electrostatics is generally to destabilize protein binding due to large desolvation penalties. A novel method for computing ligand-charge distributions that optimize the tradeoff between ligand desolvation penalty and favorable interactions with a bind...

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Sonraí Bibleagrafaíochta
Main Authors: Chong, L. T., Dempster, S. E., Hendsch, Z. S., Lee, L. P., Tidor, B.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Cold Spring Harbor Laboratory Press 1998
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2143805/
https://ncbi.nlm.nih.gov/pubmed/9514276
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