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Determinants of performance in the isocitrate dehydrogenase of Escherichia coli.

The substrate specificity of the NADP-dependent isocitrate dehydrogenase of Escherichia coli was investigated by combining site-directed mutagenesis and utilization of alternative substrates. A comparison of the kinetics of the wild-type enzyme with 2R-malate reveals that the gamma-carboxylate of 2R...

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Bibliografske podrobnosti
Main Authors: Dean, A. M., Shiau, A. K., Koshland, D. E.
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 1996
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2143340/
https://ncbi.nlm.nih.gov/pubmed/8745412
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