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A statistical mechanical model for hydrogen exchange in globular proteins.

We develop a statistical mechanical theory for the mechanism of hydrogen exchange in globular proteins. Using the HP lattice model, we explore how the solvent accessibilities of chain monomers vary as proteins fluctuate from their stable native conformations. The model explains why hydrogen exchange...

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Detalles Bibliográficos
Autores principales: Miller, D. W., Dill, K. A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Cold Spring Harbor Laboratory Press 1995
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2143224/
https://ncbi.nlm.nih.gov/pubmed/8528084
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