N-acetyl-beta-D-glucopyranosylamine: a potent T-state inhibitor of glycogen phosphorylase. A comparison with alpha-D-glucose.

Structure-based drug design has led to the discovery of a number of glucose analogue inhibitors of glycogen phosphorylase that have an increased affinity compared to alpha-D-glucose (Ki = 1.7 mM). The best inhibitor in the class of N-acyl derivatives of beta-D-glucopyranosylamine, N-acetyl-beta-D-gl...

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Detalhes bibliográficos
Main Authors: Oikonomakos, N. G., Kontou, M., Zographos, S. E., Watson, K. A., Johnson, L. N., Bichard, C. J., Fleet, G. W., Acharya, K. R.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 1995
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2143045/
https://ncbi.nlm.nih.gov/pubmed/8580837
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