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Direct observation by X-ray analysis of the tetrahedral "intermediate" of aspartic proteinases.

We report the X-ray analysis at 2.0 A resolution for crystals of the aspartic proteinase endothiapepsin (EC 3.4.23.6) complexed with a potent difluorostatone-containing tripeptide renin inhibitor (CP-81,282). The scissile bond surrogate, an electrophilic ketone, is hydrated in the complex. The pro-(...

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Hlavní autoři: Veerapandian, B., Cooper, J. B., Sali, A., Blundell, T. L., Rosati, R. L., Dominy, B. W., Damon, D. B., Hoover, D. J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 1992
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2142209/
https://ncbi.nlm.nih.gov/pubmed/1304340
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