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An action spectrum (290–320 nm) for TNFα protein in human skin in vivo suggests that basal-layer epidermal DNA is the chromophore
Terrestrial solar UVB radiation (≈295–320 nm) readily induces cyclobutane pyrimidine dimers (CPDs) in human skin DNA that result in characteristic mutations associated with nonmelanoma skin cancer. The proinflammatory cytokine TNFα is important in mouse skin chemical carcinogenesis and is thought to...
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| Huvudupphovsmän: | , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
National Academy of Sciences
2007
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2141906/ https://ncbi.nlm.nih.gov/pubmed/18025480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0703385104 |
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