Phorbol Esters and SDF-1 Induce Rapid Endocytosis and Down Modulation of the Chemokine Receptor CXCR4

The chemokine receptor CXCR4 is required, together with CD4, for entry by some isolates of HIV-1, particularly those that emerge late in infection. The use of CXCR4 by these viruses likely has profound effects on viral host range and correlates with the evolution of immunodeficiency. Stromal cell-de...

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Hauptverfasser: Signoret, Natalie, Oldridge, Joanne, Pelchen-Matthews, Annegret, Klasse, Per J., Tran, Thanh, Brass, Lawrence F., Rosenkilde, Mette M., Schwartz, Thue W., Holmes, William, Dallas, Walt, Luther, Michael A., Wells, Timothy N.C., Hoxie, James A., Marsh, Mark
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 1997
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2141706/
https://ncbi.nlm.nih.gov/pubmed/9348282
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