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Biochemical basis of SOS-induced mutagenesis in Escherichia coli: Reconstitution of in vitro lesion bypass dependent on the UmuD′(2)C mutagenic complex and RecA protein

Damage-induced SOS mutagenesis requiring the UmuD′C proteins occurs as part of the cells’ global response to DNA damage. In vitro studies on the biochemical basis of SOS mutagenesis have been hampered by difficulties in obtaining biologically active UmuC protein, which, when overproduced, is insolub...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Tang, Mengjia, Bruck, Irina, Eritja, Ramon, Turner, Jennifer, Frank, Ekaterina G., Woodgate, Roger, O’Donnell, Mike, Goodman, Myron F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21409/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9707548/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.17.9755
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