Anti-AIDS Agents 73: Structure-Activity Relationship Study and Asymmetric Synthesis of 3-O-Monomethylsuccinyl Betulinic Acid Derivatives

3-O-3′(or 2′)-methylsuccinyl-betulinic acid (MSB) derivatives were separated by using recycle HPLC. The structures of four isomers were assigned by NMR and asymmetric synthesis. 3-O-3′S-Methylsuccinyl-betulinic acid (3′S-MSB, 4) exhibited potent anti-HIV activity with an EC(50) value of 0.0087 μM an...

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Detalhes bibliográficos
Main Authors: Qian, Keduo, Nakagawa-Goto, Kyoko, Yu, Donglei, Morris-Natschke, Susan L., Nitz, Theodore J., Kilgore, Nicole, Allaway, Graham P., Lee, Kuo-Hsiung
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2140232/
https://ncbi.nlm.nih.gov/pubmed/17935987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.09.081
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