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Multiple Determinants Direct the Orientation of Signal–Anchor Proteins: The Topogenic Role of the Hydrophobic Signal Domain

The orientation of signal–anchor proteins in the endoplasmic reticulum membrane is largely determined by the charged residues flanking the apolar, membrane-spanning domain and is influenced by the folding properties of the NH(2)-terminal sequence. However, these features are not generally sufficient...

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Autors principals: Wahlberg, Johanna M., Spiess, Martin
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 1997
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2139883/
https://ncbi.nlm.nih.gov/pubmed/9151664
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