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IN VITRO STUDIES OF MAMMALIAN SOMATIC CELL VARIATION : II. ISOIMMUNE CYTOTOXICITY WITH A CULTURED MOUSE LYMPHOMA AND SELECTION OF RESISTANT VARIANTS

When long term cultures of mouse lymphoma cells, known to possess the isoantigenic phenotype determined by the H-2(d) allele, are incubated with anti H-2d isoantibody and guinea pig complement, slightly more than 99 per cent of cells are killed under optimal conditions. Growth in mass culture and co...

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Bibliographic Details
Main Authors: Cann, Howard M., Herzenberg, Leonard A.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 1963
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2137607/
https://ncbi.nlm.nih.gov/pubmed/14018309
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