Inhibition of exogenous 3-deoxy-D-manno-octulosonate incorporation into lipid A precursor of toluene-treated Salmonella typhimurium cells.

Analogs of 3-deoxy-D-manno-octulosonate (KDO) were designed to inhibit CTP:CMP-KDO cytidylyltransferase (CMP-KDO synthetase). Since these analogs lacked whole-cell antibacterial activity, a permeabilized-cell method was developed to measure intracellular compound activity directly. The method employ...

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Bibliographic Details

Published in:	J Bacteriol
Main Authors:	Capobianco, J O, Darveau, R P, Goldman, R C, Lartey, P A, Pernet, A G
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 1987
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC213704/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3040673/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.169.9.4030-4035.1987
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