NOD2 Transgenic Mice Exhibit Enhanced MDP-Mediated Down-Regulation of TLR2 Responses and Resistance to Colitis Induction

BACKGROUND AND OBJECTIVES: Mutations in the CARD15 gene affecting NOD2 function are susceptibility factors in Crohn’s disease. We set out to explore the mechanism of this susceptibility using mice that over-express NOD2. METHODS: Cellular and molecular responses of mice bearing a NOD2 transgene or a...

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Détails bibliographiques
Auteurs principaux: Yang, Zhiqiong, Fuss, Ivan J., Watanabe, Tomohiro, Asano, Naoki, Davey, Michael P., Rosenbaum, James T., Strober, Warren, Kitani, Atsushi
Format: Artigo
Langue:Inglês
Publié: 2007
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2134971/
https://ncbi.nlm.nih.gov/pubmed/17915219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2007.07.025
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