Cesium fluoride and tetra-n-butylammonium fluoride mediated 1,4-N→O shift of disubstituted phenyl ring of a bicalutamide derivative

A novel 1,4-N→O migration of a disubstituted phenyl ring was observed during N-methylation of a bicalutamide derivative, (2S)-2-(tert-butyldimethylsilanyloxy)-N-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenoxy)-2-methylpropionamide, in the presence of CsF-Celite/acetonitrile and desilylation of...

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Hlavní autoři: Patil, Renukadevi, Li, Wei, Ross, Charles R., Kraka, Elfi, Cremer, Dieter, Mohler, Michael L., Dalton, James T., Miller, Duane D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2134913/
https://ncbi.nlm.nih.gov/pubmed/18079983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2006.03.154
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