Inhibition of NF-κB activation in macrophages increases atherosclerosis in LDL receptor–deficient mice

Atherosclerosis is now generally accepted as a chronic inflammatory condition. The transcription factor NF-κB is a key regulator of inflammation, immune responses, cell survival, and cell proliferation. To investigate the role of NF-κB activation in macrophages during atherogenesis, we used LDL rece...

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Main Authors: Kanters, Edwin, Pasparakis, Manolis, Gijbels, Marion J.J., Vergouwe, Monique N., Partouns-Hendriks, Iris, Fijneman, Remond J.A., Clausen, Björn E., Förster, Irmgard, Kockx, Mark M., Rajewsky, Klaus, Kraal, Georg, Hofker, Marten H., de Winther, Menno P.J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC213488/
https://ncbi.nlm.nih.gov/pubmed/14561702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200318580
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https://ncbi.nlm.nih.gov/pmc/articles/PMC213488/
https://ncbi.nlm.nih.gov/pubmed/14561702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200318580