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Monocyte Adhesion and Spreading on Human Endothelial Cells Is Dependent on Rho-regulated Receptor Clustering

The GTPase Rho is known to mediate the assembly of integrin-containing focal adhesions and actin stress fibers. Here, we investigate the role of Rho in regulating the distribution of the monocyte-binding receptors E-selectin, ICAM-1, and VCAM-1 in human endothelial cells. Inhibition of Rho activity...

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Bibliographic Details
Main Authors: Wójciak-Stothard, Beata, Williams, Lynn, Ridley, Anne J.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 1999
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2133155/
https://ncbi.nlm.nih.gov/pubmed/10366600
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