GalNAc-α-O-benzyl Inhibits NeuAcα2-3 Glycosylation and Blocks the Intracellular Transport of Apical Glycoproteins and Mucus in Differentiated HT-29 Cells

Exposure for 24 h of mucus-secreting HT-29 cells to the sugar analogue GalNAc-α-O-benzyl results in inhibition of Galβ1-3GalNAc:α2,3-sialyltransferase, reduced mucin sialylation, and inhibition of their secretion (Huet, G., I. Kim, C. de Bolos, J.M. Loguidice, O. Moreau, B. Hémon, C. Richet, P. Dela...

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Hauptverfasser: Huet, Guillemette, Hennebicq-Reig, Sylviane, de Bolos, Carmen, Ulloa, Fausto, Lesuffleur, Thécla, Barbat, Alain, Carrière, Véronique, Kim, Isabelle, Real, Francisco X., Delannoy, Philippe, Zweibaum, Alain
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 1998
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2132799/
https://ncbi.nlm.nih.gov/pubmed/9628888
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