Extension of the substrate spectrum by an amino acid substitution at residue 219 in the Citrobacter freundii cephalosporinase.

The cephalosporinase of Citrobacter freundii GN346 is a class C beta-lactamase, consisting of 361 amino acids and exhibiting the substrate profile of a typical cephalosporinase. On the conversion of a conserved glutamic acid at residue 219 to lysine, the substrate spectrum of the cephalosporinase wa...

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Veröffentlicht in:	J Bacteriol
Hauptverfasser:	Tsukamoto, K, Ohno, R, Sawai, T
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1990
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC213260/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2115867/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.172.8.4348-4351.1990
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