Overexpression of a Streptomyces viridochromogenes gene (glnII) encoding a glutamine synthetase similar to those of eucaryotes confers resistance against the antibiotic phosphinothricyl-alanyl-alanine.

Phosphinothricyl-alanyl-alanine (PTT), also known as bialaphos, contains phosphinothricin, a potent inhibitor of glutamine synthetase (GS). A 2.75-kilobase NcoI fragment of the Streptomyces viridochromogenes PTT-resistant mutant ES2 cloned on a multicopy vector mediated PTT resistance to S. lividans...

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Main Authors: Behrmann, I, Hillemann, D, Pühler, A, Strauch, E, Wohlleben, W
Formato: Artigo
Idioma:Inglês
Publicado em: 1990
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC213196/
https://ncbi.nlm.nih.gov/pubmed/1975583
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