Overexpression of a Streptomyces viridochromogenes gene (glnII) encoding a glutamine synthetase similar to those of eucaryotes confers resistance against the antibiotic phosphinothricyl-alanyl-alanine.

Phosphinothricyl-alanyl-alanine (PTT), also known as bialaphos, contains phosphinothricin, a potent inhibitor of glutamine synthetase (GS). A 2.75-kilobase NcoI fragment of the Streptomyces viridochromogenes PTT-resistant mutant ES2 cloned on a multicopy vector mediated PTT resistance to S. lividans...

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Detalhes bibliográficos

Publicado no:	J Bacteriol
Principais autores:	Behrmann, I, Hillemann, D, Pühler, A, Strauch, E, Wohlleben, W
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC213196/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1975583/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.172.9.5326-5334.1990
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