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Abrogation of lupus nephritis in Activation-Induced Deaminase-deficient MRL/lpr Mice
We generated MRL/lpr mice deficient in the Activation Induced Deaminase (AID). Because AID is required for immunoglobulin hypermutation and class switch recombination, these mice lack hypermutated IgG antibodies. Unlike their AID wild-type littermates, AID-deficient MRL/lpr mice not only lacked auto...
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Главные авторы: | , , , , , , |
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Формат: | Artigo |
Язык: | Inglês |
Опубликовано: |
2007
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Предметы: | |
Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2131724/ https://ncbi.nlm.nih.gov/pubmed/17513793 |
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