Pirfenidone Prevents the Development of a Vulnerable Substrate for Atrial Fibrillation in a Canine Model of Heart Failure

BACKGROUND: Atrial fibrosis is an important substrate in atrial fibrillation (AF), particularly in the setting of structural heart disease. In a canine model, congestive heart failure (CHF) produces significant atrial fibrosis and the substrate for sustained AF. This atrial remodeling is a potential...

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Main Authors: Lee, Ken W., Everett, Thomas H., Rahmutula, Dulkon, Guerra, Jose M., Wilson, Emily, Ding, Chunhua, Olgin, Jeffrey E.
Format: Artigo
Jezik:Inglês
Izdano: 2006
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2129103/
https://ncbi.nlm.nih.gov/pubmed/17030685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.106.624320
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