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Transcriptional upregulation of p57 (Kip2) by the cyclin dependent kinase inhibitor BMS-387032 is E2F dependent and serves as a negative feedback loop limiting cytotoxicity
In spite of the fact that cdk inhibiting drugs are also potent transcriptional inhibitors, we discover that p57 (Kip2, CDKN1C) is significantly upregulated by three small molecule cdk inhibitors, including BMS-387032 (SNS-032). Herein, several lines of evidence demonstrate that p57 upregulation by B...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2128050/ https://ncbi.nlm.nih.gov/pubmed/17173074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.onc.1210143 |
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