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Solution structure of the MEF2A–DNA complex: structural basis for the modulation of DNA bending and specificity by MADS-box transcription factors

The solution structure of the 33 kDa complex between the dimeric DNA-binding core domain of the transcription factor MEF2A (residues 1–85) and a 20mer DNA oligonucleotide comprising the consensus sequence CTA(A/T)(4)TAG has been solved by NMR. The protein comprises two domains: a MADS-box (residues...

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Detalhes bibliográficos
Main Authors: Huang, Kai, M.Louis, John, Donaldson, Logan, Lim, Fei-Ling, D.Sharrocks, Andrew, Clore, G.Marius
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC212754/
https://ncbi.nlm.nih.gov/pubmed/10835359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.11.2615
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