Covalent modification of the active site threonine of proteasomal β subunits and the Escherichia coli homolog HslV by a new class of inhibitors

The proteasome is a multicatalytic protease complex that plays a key role in diverse cellular functions. The peptide vinyl sulfone, carboxybenzyl-leucyl-leucyl-leucine vinyl sulfone (Z-L(3)VS) covalently inhibits the trypsin-like, chymotrypsin-like and, unlike lactacystin, also the peptidylglutamyl...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Bogyo, Matthew, McMaster, John S., Gaczynska, Maria, Tortorella, Domenico, Goldberg, Alfred L., Ploegh, Hidde
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21209/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9192616/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.13.6629
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