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Lysosome biogenesis requires Rab9 function and receptor recycling from endosomes to the trans-Golgi network
Newly synthesized lysosomal enzymes bind to mannose 6-phosphate receptors (MPRs) in the TGN, and are carried to prelysosomes, where they are released. MPRs then return to the TGN for another round of transport. Rab9 is a ras-like GTPase which facilitates MPR recycling to the TGN in vitro. We show he...
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| Formato: | Artigo |
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| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
1994
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2119986/ https://ncbi.nlm.nih.gov/pubmed/7909812 |
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