Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function

It has been suggested that T cell immunoglobulin mucin (Tim)-1 expressed on T cells serves to positively costimulate T cell responses. However, crosslinking of Tim-1 by its ligand Tim-4 resulted in either activation or inhibition of T cell responses, thus raising the issue of whether Tim-1 can have...

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Main Authors: Xiao, Sheng, Najafian, Nader, Reddy, Jay, Albin, Monica, Zhu, Chen, Jensen, Eric, Imitola, Jaime, Korn, Thomas, Anderson, Ana C., Zhang, Zheng, Gutierrez, Cristina, Moll, Thomas, Sobel, Raymond A., Umetsu, Dale T., Yagita, Hideo, Akiba, Hisaya, Strom, Terry, Sayegh, Mohamed H., DeKruyff, Rosemarie H., Khoury, Samia J., Kuchroo, Vijay K.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118637/
https://ncbi.nlm.nih.gov/pubmed/17606630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20062498
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