Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction

In autoimmune arthritis, traditionally classified as a T helper (Th) type 1 disease, the activation of T cells results in bone destruction mediated by osteoclasts, but how T cells enhance osteoclastogenesis despite the anti-osteoclastogenic effect of interferon (IFN)-γ remains to be elucidated. Here...

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Autori principali: Sato, Kojiro, Suematsu, Ayako, Okamoto, Kazuo, Yamaguchi, Akira, Morishita, Yasuyuki, Kadono, Yuho, Tanaka, Sakae, Kodama, Tatsuhiko, Akira, Shizuo, Iwakura, Yoichiro, Cua, Daniel J., Takayanagi, Hiroshi
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2006
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Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118166/
https://ncbi.nlm.nih.gov/pubmed/17088434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20061775
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