Functional disruption of α4 integrin mobilizes bone marrow–derived endothelial progenitors and augments ischemic neovascularization

The cell surface receptor α4 integrin plays a critical role in the homing, engraftment, and maintenance of hematopoietic progenitor cells (HPCs) in the bone marrow (BM). Down-regulation or functional blockade of α4 integrin or its ligand vascular cell adhesion molecule-1 mobilizes long-term HPCs. We...

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Main Authors: Qin, Gangjian, Ii, Masaaki, Silver, Marcy, Wecker, Andrea, Bord, Evelyn, Ma, Hong, Gavin, Mary, Goukassian, David A., Yoon, Young-sup, Papayannopoulou, Thalia, Asahara, Takayuki, Kearney, Marianne, Thorne, Tina, Curry, Cynthia, Eaton, Liz, Heyd, Lindsay, Dinesh, Deepika, Kishore, Raj, Zhu, Yan, Losordo, Douglas W.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2006
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118065/
https://ncbi.nlm.nih.gov/pubmed/16401693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050459
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