Safety and tolerability of adjunctive tolcapone treatment in patients with early Parkinson's disease

OBJECTIVE: The safety and tolerability of adjunctive tolcapone initiated simultaneously with levodopa was evaluated with a focus on increases in liver transaminase and hepatotoxicity. METHODS: 677 levodopa‐naïve patients with early stage Parkinson's disease (PD) were randomised to receive place...

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Hlavní autoři: Lees, A J, Ratziu, V, Tolosa, E, Oertel, W H
Médium: Artigo
Jazyk:Inglês
Vydáno: BMJ Group 2007
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Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2117861/
https://ncbi.nlm.nih.gov/pubmed/17098835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jnnp.2006.097154
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