ABNORMAL GLUTAMATE HOMEOSTASIS AND IMPAIRED SYNAPTIC PLASTICITY AND LEARNING IN A MOUSE MODEL OF TUBEROUS SCLEROSIS COMPLEX

Mice with inactivation of the Tuberous sclerosis complex-1 (Tsc1) gene in glia (Tsc1(GFAP)CKO mice) have deficient astrocyte glutamate transporters and develop seizures, suggesting that abnormal glutamate homeostasis contributes to neurological abnormalities in these mice. We examined the hypothesis...

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Main Authors: Zeng, Ling-Hui, Ouyang, Yannan, Gazit, Vered, Cirrito, John R., Jansen, Laura A., Ess, Kevin C., Yamada, Kelvin A., Wozniak, David F., Holtzman, David M., Gutmann, David H., Wong, Michael
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2117357/
https://ncbi.nlm.nih.gov/pubmed/17714952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2007.07.015
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