Nitrosylcobalamin Potentiates the Anti-Neoplastic Effects of Chemotherapeutic Agents via Suppression of Survival Signaling

BACKGROUND: Nitrosylcobalamin (NO-Cbl) is a chemotherapeutic pro-drug derived from vitamin B12 that preferentially delivers nitric oxide (NO) to tumor cells, based upon increased receptor expression. NO-Cbl induces Apo2L/TRAIL-mediated apoptosis and inhibits survival signaling in a variety of malign...

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Main Authors: Bauer, Joseph A., Lupica, Joseph A., Schmidt, Heidi, Morrison, Bei H., Haney, Rebecca M., Masci, Rhonda K., Lee, Rebecca M., DiDonato, Joseph A., Lindner, Daniel J.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2007
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2117345/
https://ncbi.nlm.nih.gov/pubmed/18074035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001313
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