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Effect of an MMP‐9/MMP‐12 inhibitor on smoke‐induced emphysema and airway remodelling in guinea pigs

BACKGROUND: Matrix metalloproteases (MMPs) are believed to be important in the pathogenesis of cigarette smoke‐induced emphysema, but this hypothesis has only been proved in the mouse and its applicability to other species, particularly humans, is uncertain. The role of MMPs in smoke‐induced small a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Churg, Andrew, Wang, Rona, Wang, Xiaoshan, Onnervik, Per‐Ola, Thim, Kerstin, Wright, Joanne L
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMJ Group 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2117295/
https://ncbi.nlm.nih.gov/pubmed/17311841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/thx.2006.068353
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