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Growth hormone-releasing hormone antagonist MZ-5-156 inhibits growth of DU-145 human androgen-independent prostate carcinoma in nude mice and suppresses the levels and mRNA expression of insulin-like growth factor II in tumors

Insulin-like growth factors I and II (IGF-I and -II) are potent mitogens for various cancers, including carcinoma of the prostate. In several experimental cancers, treatment with antagonists of growth hormone-releasing hormone (GH-RH) produces a reduction in IGF-I and -II, concomitant to inhibition...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Lamharzi, Najib, Schally, Andrew V., Koppán, Miklós, Groot, Kate
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1998
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21168/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9671770/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.15.8864
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