Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2

Angiogenesis is required for tumor growth and metastasis, and inhibition of angiogenesis is a promising approach for anticancer therapy. Tie2 (a.k.a Tek) is an endothelium-specific receptor tyrosine kinase known to play a role in tumor angiogenesis. To explore the therapeutic potential of blocking t...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Lin, Pengnian, Buxton, Jake A., Acheson, Ann, Radziejewski, Czeslaw, Maisonpierre, Peter C., Yancopoulos, George D., Channon, Keith M., Hale, Laura P., Dewhirst, Mark W., George, Samuel E., Peters, Kevin G.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1998
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21162/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9671764/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.15.8829
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